Age-related increase in liver retinyl palmitate. Relationship to lipofuscin.
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چکیده
منابع مشابه
Unusual properties of retinyl palmitate hydrolase activity in rat liver.
These studies report the hydrolysis of retinyl palmitate with liver homogenates and homogenate fractions from retinol-depleted rats. The studies utilized an effective in vitro assay for retinyl palmitate hydrolase (RPH) activity, in which microgram amounts of retinyl palmitate were employed as substrate, followed by the chromatographic separation and fluorescence assay of free and esterified re...
متن کاملRetinyl palmitate hydrolase activity in normal rat liver.
Retinyl esters are hydrolyzed in liver both during uptake and mobilization of vitamin A. Studies were conducted to explore the enzymatic hydrolysis of retinyl palmitate in normal rat liver. Retinyl palmitate hydrolase activity was assayed with a sensitive and accurate microassay, employing retinyl [~-‘~C]palmitate as substrate. The products of the reaction were identified as retinol and free fa...
متن کاملPharmacokinetics of retinyl palmitate and retinol after intramuscular retinyl palmitate administration in severe malaria.
Retinol (vitamin A alcohol) is an accepted adjunctive treatment in infections such as measles. There is also indirect evidence from in vitro, animal and human studies that retinol supplementation may be beneficial in severe malaria. There have, however, been no studies that have examined the pharmacokinetics of acute retinol supplementation in severe illness. To establish whether mobilization o...
متن کاملRetinoids, retinoid-binding proteins, and retinyl palmitate hydrolase distributions in different types of rat liver cells.
A study was conducted to determine the levels and distributions of retinoids, retinol-binding protein (RBP), retinyl palmitate hydrolase (RPH), cellular retinol-binding protein (CRBP), and cellular retinoic acid-binding protein (CRABP) in different types of isolated liver cells. Highly purified fractions of parenchymal, fat-storing (stellate), endothelial, and Kupffer cells were isolated in hig...
متن کاملChylomicron-retinyl palmitate clearance in type I hyperlipidemic families.
Our primary aim was to determine the extent to which intraplasmic retinyl palmitate (RP) transfers to other lipoprotein particles when chylomicron remnants are not produced and/or the plasma RP residence time is increased. The study was conducted on three familial type I hyperlipoproteinemic patients, four lipoprotein lipase (LpL)-deficient heterozygotes, and three controls on a metabolic resea...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1994
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(17)37026-6